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Showing 6 results for Rami
The effects Safflower Seed (A new variety of pigmented coat seeds) Consumption on the Liver and Kidney Tissues of Male Wistar Rats
Soraya Karami, Layasadat Khorsandi,
Volume 4, Issue 1 (5-2016)
Abstract

Background and Objectives: Seeds of cultivated safflower which are now used in pharmaceutical and food industries are in white coat color. No commercially available pigmented genotype of cultivated safflower has been reported yet. This study was to investigate the probable toxicological effects of black coat seed of a new pigmented variety of safflower (A82) on liver and kidney tissues of male wistar rats.

Methods: In the present experimental study, 54 male wistar rats were randomly divided into 2 groups of 24 (including 4 subgroups of 6 rats) and a control group of 6 rats. Group 1 (control group), distilled water, group 2 (CTBS) and Group 3 (CTWS) were respectively given grain crust suspension (A82) and white shell (C111) safflower on a daily basis, at doses of 30, 60, 180 and 240 mg per kg body weight orally for 5 weeks. In order to address the biochemical tests including alanine aminotransferase (ALT), aspartate aminotransferase (AST) ,alkaline phosphatase (ALP), blood urea nitrogen (BUN) and creatinine (Cr), arterial blood samples were taken. Regarding histological studies, liver and kidney organs were removed immediately. After fixation of samples in 10% formalin, 4-5 µm tissue sections were prepared. Hematoxylin and Eosin (H&E) staining method followed by light microscopy was used to examine the sections. One-way ANOVA was used to compare the means between groups and least significant difference (LSD) was used to perform additional tests.

Results: In both CTBS and CTWS treatment groups, the body weight of wistar rats increased significantly in a dose-dependent manner (233.00±4.74 and 218.76±5.43, respectively) compared to the control group (196.79±4.88). The increasing trend was significantly higher in CTBS group compared to the CTWS group (p<0.05). In contrast to the results of body weight, organ weights of liver and kidney treatment groups were not significantly changed in all treatment groups. The serum levels of ALT and AST showed no significant difference between treatment groups and also in comparison to the control group. The serum level of ALP within CTBS treatment group (567.39±32.5) was significantly lower than CTWS (609.94±30.5) and control groups (819.50±38.21) (p<0.05). BUN and Cr were decreased among treatment groups in comparison to the control group (p>0.05). Moreover, regarding histopathological studies, neither liver nor kidney necrosis or damages were visualized in treatment groups in a dose-dependent manner.

Conclusion: Our findings showed that safflower seed, especially black ones (A82) has no toxic effects over liver and kidney tissues. The positive effects of black seeds on body weight among wistar rats may be an interesting effect to be further investigated for exploitation in the poultry industry.


Investigating the mediating role of attachment styles in explaining the relationship between temperament, character dimensions and somatization disorders among female teachers in Kermanshah
Dr Jahangir Karami, Dr Kamran Yazdanbakhsh, Parvaneh Karimi,
Volume 5, Issue 1 (5-2017)
Abstract
Background & Objective: According to the importance of somatization disorder in women, this study was conducted to investigate the mediating role of attachment styles in relationship with temperament and character dimensions of personality and somatization disorder among female teachers in Kermanshah city.
Methods: The study population consisted of all female teachers working in Kermanshah educational system in 2013-2014. The sample population included 300 teachers who were allocated by multistep cluster sampling. They were asked to complete Cloninger Temperament and character Inventor Questionnaire (TCI), somatization questionnaire and Adult Attachment Styles Inventory Questionnaire (AII). The data analysis was done by correlation coefficient calculation and path analysis using SPSS 21.0 and Amos 18.0 software.  
Results: Our findings showed that there was a significant correlation between anxiety and avoidance attachment styles and dimensions of personality with somatoform disorder. However, the relationship between safe attachment style and physical disorder was not significant.
Conclusion: Temperament and character dimensions of personality result in somatization disorder when the insecure internal models which are set according to the framework of mother-neonate attachment relationships had been formed.

Histone Methylation in StAR Gene Promoter Using Follicular Granulosa Cells Extracted from the Women Referring to a Fertility Clinic in Tabriz, Iran
Telnaz Bahrami, Masoud Maleki,
Volume 7, Issue 2 (7-2019)
Abstract
Infertility is a disorder of the reproductive system, which often occurs after one year of regular unprotected intercourse with the aim of pregnancy. Several physical functions require the synthesis of steroid hormones, in which gonadal steroids (estrogen and progesterone) play a pivotal role in reproduction. Follicular growth and ovulation depend on the proliferation and differentiation of the granulosa and theca cells, which are possible in the steroid pathway after stimulation with the ovarian gonadotropins and cytokines. Steroidization is initiated with the transfer of cholesterol by the StAR protein to the mitochondrial membrane of the steroid cells, which is followed by a cascade of steroid hormones. Recent studies have highlighted the impact of epigenetic mechanisms on reproduction, emphasizing the importance of these changes in the early and secondary stages of gametogenesis. To determine the causes of infertility, it is essential to recognize the altered epigenetic modifications of the relevant gene and its mechanisms. In the present study, the H3K4me3 methylation level was evaluated in the StAR gene regulatory region in the granulosa cells collected from the fertile and infertile women referring to Tabriz Jihad Infertility Centerin Tabriz, Iran using ChIP-qPCR. According to the results, the H3K4me3 methylation level increased in the StAR gene regulatory region in the fertile women compared to the infertile women. In addition, a significant correlation was observed between the follicle and egg rates at the MII stage and the level of this methylation.
The evaluation of mandibular canal visibility on cone beam computed tomography (CBCT) images: A cross-sectional study
Seyed Hossein Razavi , Soudeh Berahmand , Khalil Sarikhani Khorami , Motahareh Kaboodsaz Yazdi, Nasim Namiranian ,
Volume 7, Issue 3 (9-2019)
Abstract
Background and objectives: An effective factor in choosing the correct place for the dental implant and performing surgical procedures in the posterior regions of mandible is the position of the mandibular canal. Failure to consider this important landmark will damage the inferior alveolar nerve. Considering the widespread use of implants and the precision of the images obtained from CBCT. The aim of this study was to evaluate the rate of visibility of mandibular canal by CBCT in order to prevent damage to the inferior alveolar nerves and arteries.
Material And Methods: In this study, 90 archived CBCT images of patients from a private center of oral and maxillofacial radiology in Yazd that was taken by technician was evaluated during 2012-2019. The visibility of the mandibular canal in reconstructed panoramic images of CBCT was assessed by a dentistry student trained by the maxillofacial radiologist in five areas in different thicknesses on each side. Data were analyzed using SPSS 17 software. Chi-square, and correlation coefficient were done.
Results: In total, in 53.38% of CBCT images both borders of mandibular canal were visible, in 17.95%, only one border was visible (difficult observation) and in 28.7% of cases, lack of visibility of mandibular canal was reported. There was no significant difference between sex, age, side and thickness in mandibular canal visibility (P >0.05).
Conclusion: In more than half of CBCT images, both borders were clearly visible in both right and left sides; therefore we can conclude that CBCT is a useful tool for the observation of mandibular canal before surgeries.

Prevalence, dimension and location of retromolar canal on cone beam computed tomography: An Analytical cross sectional study
Khalil Sarikhani Khorami , Fatemeh Ezoddini Ardakani , Yaser Safi , Motahare Baghestani,
Volume 7, Issue 3 (9-2019)
Abstract
Background and objectives: The retromolar canal is an anatomical variant that needs consideration in local anesthesia and surgical procedures involving the retromolar area. Complications such as local anesthetic insufficiency, a sensory deficit, hemorrhage and traumatic neuroma may arise in the absence of recognition of these variants. The aim of this study is to determine the prevalence and course of retromolar canal in the Iranian population.
Methods: This study is a descriptive cross sectional study. The cross sectional sagittal and three dimensional images from volumetric CBCT. data of 270 patients were reconstructed using on demand imaging analysis software. Retromolar canals were classified into two types according to the courses. The width and location (distance from the third molar) of retromolar canals were evaluated. Results were analyzed with SPSS 20 software and were assessed using the t_test and chi_square test.
Results: Retromolar canal was observed in 9/25 % of patients. The mean width of the retromolar foramen was 1/43 mm, and the mean distance from anterior border of retromolar foramen to the distal CEJ of the second molar was 13/33 mm.
Conclusion: The prevalence of retromolar canals in the Iranian population was lower than that was reported in previous studies. It can be observed in 9/25 % of Iranian patients.  Damage to the retromolar canal may be unavoidable during surgical procedures may result in paresthesia, excessive bleeding, postoperative hematoma, or traumatic neuroma. Therefore, the clinician must pay particular attention to the identification of a retromolar canal by preoperative radiographic examination and additional CBCT scanning is recommended.

The effect of six weeks HIIT exercise on the gene expression of some inflammatory and anti-inflammatory markers of hippocampal tissue in aged male Wistar rats
Sara Ghasdi , Mohammad Rami , Abdolhamid Habibi ,
Volume 13, Issue 1 (9-2025)
Abstract
Background: Research has shown that high-intensity interval training (HIIT) is a convenient and time-efficient approach that promotes oxidative capacity. Therefore, this study aimed to investigate the effect of HIIT on the gene expression of some inflammatory and anti-inflammatory markers of hippocampal tissue in aged male Wistar rats.
Methods: In this experimental study, 21 male Wistar rats were divided into three equal groups: 1- control (C), 2- elderly control (EC), and 3- elderly training (ET). After two weeks of adaptation to the laboratory environment, six weeks of HIIT were performed for the training group. Forty-eight hours after the last training session, hippocampal tissue was isolated to examine the mean levels of interleukin-10 (IL-10), IL-6, and IL-1β gene expression. One-way analysis of variance and Tukey's post-hoc test with a significance level of 0.05 were used to analyze the data.
Results: There was a significant increase in the expression of IL-6 and IL-1β, while a significant decrease in IL-10 expression (p=0.001) in the C group compared to the EC. After six weeks of HIIT, expression of IL-6 (p=0.001) and IL-1β (p=0.001) significantly decreased, whereas IL-10 expression significantly increased (p=0.001) in the ET group compared to the EC group.
Conclusion: It seems that HIIT activity has beneficial effects on preventing the process of neural degeneration. Moreover, it is promising as a non-pharmacological strategy for controlling complications resulting from the aging process due to its anti-inflammatory properties.

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