Volume 6, Issue 1 (3-2018)  

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  • It has been suggested that various epigenetic deviations play a major role in the pathogenesis of endometriosis.
  • Steroidogenic factor 1 (SF-1; NR5A1) is an essential transcription factor for estrogen biosynthesis in endometrial cells.
  • Here, we aimed to compare the methylation status of the SF-1 gene promoter region in women with endometriosis in comparison to healthy subjects.
  • The methylation status of SF-1 gene promoter was decreased significantly in endometriosis samples.  
  • SF-1 gene promoter hypomethylation could increase the relative expression of SF-1 gene in endometriosis which may lead to the development or progression of the disease.

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