Volume 10, Issue 1 (3-2022)                   Jorjani Biomed J 2022, 10(1): 67-83 | Back to browse issues page


XML Print


1- Department of Microbiology, Golestan University of Medical Sciences, Gorgan, Iran
2- Department of Biochemistry and Biophysics, Metabolic Disorders Research Center, School of Medicine, Golestan University of Medical Science, Gorgan, Iran
3- Department of Microbiology, Golestan University of Medical Sciences, Gorgan, Iran , hamidi.v@goums.ac.ir
Abstract:   (4400 Views)
Vitamin A is fat-soluble compounds of retinoid derivate, consisting of retinol, retinal, and retinyl esters. Vitamin A also affects cell growth and differentiation, playing a critical role in the normal formation and function of the heart, lungs, kidneys, and other organs. According to the role of vitamin A in enhancing immune function, it is known as an anti-inflammatory agent. Also, vitamin A supplementation by reducing morbidity and mortality in different infectious diseases, such as measles, diarrheal disease, measles-related pneumonia, human immunodeficiency virus infection, and malaria considered as a crucial factor against infection. So vitamin A deficiency can be life-threatening, because of impairing the response to infection and significant risk of development of severe respiratory infections in infants and young children. In this paper, we have discussed the effects of vitamin A in modulating immune responses in viral infections and the direct effects of this vitamin on viral replication by comparing its role during different types of viral infections.
Full-Text [PDF 942 kb]   (1121 Downloads) |   |   Full-Text (HTML)  (153 Views)  


 Vitamin A has direct and indirect effects in modulating immune responses
 Vitamin A deficiency is involved in the severity of different  viral infections
 Vitamin A is an important element in cytokine storm
Type of Article: Review Article | Subject: Basic Medical Sciences
Received: 2021/12/14 | Accepted: 2022/03/6 | Published: 2022/03/30

References
1. D'Ambrosio D, Clugston R, Blaner W, D'Ambrosio D, Clugston R, Blaner W. Vitamin A Metabolism: An Update. Nutrients, 3, 63-103. 2011. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
2. Napoli JL. Biochemical pathways of retinoid transport, metabolism, and signal transduction. Clinical immunology and immunopathology. 1996;80(3):S52-S62. [view at publisher] [DOI] [PMID] [Google Scholar]
3. Joint F. WHO Expert Consultation on Human vitamin and mineral requirements. Vitamin and mineral requirements in human nutrition: report of a joint FAO/WHO expert consultation, Bangkok, Thailand. 1998;2. [Google Scholar]
4. Warkany J, Schraffenberger E. Congenital malformations induced in rats by maternal vitamin A deficiency: I. Defects of the eye. Archives of ophthalmology. 1946;35(2):150-69. [view at publisher] [DOI] [PMID] [Google Scholar]
5. Patel S, Vajdy M. Induction of cellular and molecular immunomodulatory pathways by vitamin A and flavonoids. Expert opinion on biological therapy. 2015;15(10):1411-28. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
6. Yu M, Vajdy M. A novel retinoic acid, catechin hydrate and mustard oil-based emulsion for enhanced cytokine and antibody responses against multiple strains of HIV-1 following mucosal and systemic vaccinations. Vaccine. 2011;29(13):2429-36. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
7. Vajdy M. Immunomodulatory properties of vitamins, flavonoids and plant oils and their potential as vaccine adjuvants and delivery systems. Expert opinion on biological therapy. 2011;11(11):1501-13. [view at publisher] [DOI] [PMID] [Google Scholar]
8. D'Ambrosio DN, Clugston RD, Blaner WS. Vitamin A metabolism: an update. Nutrients. 2011;3(1):63-103. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
9. Blomhoff R, Green MH, Green JB, Berg T, Norum KR. Vitamin A metabolism: new perspectives on absorption, transport, and storage. Physiological reviews. 1991;71(4):951-90. [view at publisher] [DOI] [PMID] [Google Scholar]
10. Ong DE. Absorption of vitamin A. Vitamin A in health and disease: Marcel Dekker, New York; 1994. p. 37-72.
11. Parker RS. Absorption, metabolism, and transport of carotenoids. The FASEB Journal. 1996;10(5):542-51. [DOI] [PMID]
12. Stephensen CB. Vitamin A, infection, and immune function. Annual review of nutrition. 2001;21(1):167-92. [view at publisher] [DOI] [PMID] [Google Scholar]
13. Engedal N, Gjevik T, Blomhoff R, Blomhoff HK. All-trans retinoic acid stimulates IL-2-mediated proliferation of human T lymphocytes: early induction of cyclin D3. The Journal of Immunology. 2006;177(5):2851-61. [view at publisher] [DOI] [PMID] [Google Scholar]
14. Mark M, Ghyselinck NB, Chambon P. Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis. Annu Rev Pharmacol Toxicol. 2006;46:451-80. [view at publisher] [DOI] [PMID] [Google Scholar]
15. Barclay A, Foster A, Sommer A. Vitamin A supplements and mortality related to measles: a randomised clinical trial. Br Med J (Clin Res Ed). 1987;294(6567):294-6. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
16. Coutsoudis A, Broughton M, Coovadia HM. Vitamin A supplementation reduces measles morbidity in young African children: a randomized, placebo-controlled, double-blind trial. The American journal of clinical nutrition. 1991;54(5):890-5. [view at publisher] [DOI] [PMID] [Google Scholar]
17. Sommer A, Katz J, Tarwotjo I. Increased risk of respiratory disease and diarrhea in children with preexisting mild vitamin A deficiency. The American journal of clinical nutrition. 1984;40(5):1090-5. [view at publisher] [DOI] [PMID] [Google Scholar]
18. Hossain S, Biswas R, Kabir I, Sarker S, Dibley M, Fuchs G, et al. Single dose vitamin A treatment in acute shigellosis in Bangladeshi children: randomised double blind controlled trial. Bmj. 1998;316(7129):422-6. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
19. Neuman MI, Willett WC, Curhan GC. Vitamin and micronutrient intake and the risk of community-acquired pneumonia in US women. The American journal of medicine. 2007;120(4):330-6. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
20. Rahman MM, Mahalanabis D, Alvarez J, Wahed M, Islam M, Habte D, et al. Acute respiratory infections prevent improvement of vitamin A status in young infants supplemented with vitamin A. The Journal of nutrition. 1996;126(3):628-33. [view at publisher] [DOI] [PMID] [Google Scholar]
21. Metzger A, Mukasa G, Shankar AH, Ndeezi G, Melikian G, Semba RD. Antioxidant status and acute malaria in children in Kampala, Uganda. The American journal of tropical medicine and hygiene. 2001;65(2):115-9. [DOI] [PMID] [Google Scholar]
22. Nussenblatt V, Semba RD. Micronutrient malnutrition and the pathogenesis of malarial anemia. Acta Tropica. 2002;82(3):321-37. [view at publisher] [DOI] [Google Scholar]
23. Semba RD, Tang AM. Micronutrients and the pathogenesis of human immunodeficiency virus infection. British Journal of Nutrition. 1999;81(3):181-9. [view at publisher] [DOI] [PMID] [Google Scholar]
24. Coutsoudis A, Bobat R, Coovadia HM, Kuhn L, Tsai W-Y, Stein ZA. The effects of vitamin A supplementation on the morbidity of children born to HIV-infected women. American Journal of Public Health. 1995;85(8_Pt_1):1076-81. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
25. Penkert RR, Jones BG, Häcker H, Partridge JF, Hurwitz JL. Vitamin A differentially regulates cytokine expression in respiratory epithelial and macrophage cell lines. Cytokine. 2017;91:1-5. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
26. Semba RD. Vitamin A and immunity to viral, bacterial and protozoan infections. Proceedings of the Nutrition Society. 1999;58(3):719-27. [view at publisher] [DOI] [PMID] [Google Scholar]
27. Stošić-Grujičić S, Ejdus L. Modulation of in vitro T cell alloreactivity by synthetic retinoids. Immunopharmacology. 1994;27(2):87-92. [view at publisher] [DOI] [Google Scholar]
28. Dong P, Tao Y, Yang Y, Wang W. Expression of retinoic acid receptors in intestinal mucosa and the effect of vitamin A on mucosal immunity. Nutrition. 2010;26(7-8):740-5. [view at publisher] [DOI] [PMID] [Google Scholar]
29. Kaufman DR, De Calisto J, Simmons NL, Cruz AN, Villablanca EJ, Mora JR, et al. Vitamin A deficiency impairs vaccine-elicited gastrointestinal immunity. The Journal of Immunology. 2011;187(4):1877-83. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
30. Semba RD, Scott AL, Natadisastra G, Wirasasmita S, Mele L, Ridwan E, et al. Depressed immune response to tetanus in children with vitamin A deficiency. The Journal of nutrition. 1992;122(1):101-7. [view at publisher] [DOI] [PMID] [Google Scholar]
31. Semba RD, Scott AL, Natadisastra G, West K, Sommer A. Effect of vitamin A supplementation on immunoglobulin G subclass responses to tetanus toxoid in children. Clin Diagn Lab Immunol. 1994;1(2):172-5. [DOI] [PMID] [PMCID] [Google Scholar]
32. Mora JR, Iwata M, Eksteen B, Song S-Y, Junt T, Senman B, et al. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science. 2006;314(5802):1157-60. [view at publisher] [DOI] [PMID] [Google Scholar]
33. Iwata M, Hirakiyama A, Eshima Y, Kagechika H, Kato C, Song S-Y. Retinoic acid imprints gut-homing specificity on T cells. Immunity. 2004;21(4):527-38. [view at publisher] [DOI] [PMID] [Google Scholar]
34. Mora JR, Bono MR, Manjunath N, Weninger W, Cavanagh LL, Rosemblatt M, et al. Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells. Nature. 2003;424(6944):88-93. [view at publisher] [DOI] [PMID] [Google Scholar]
35. Mora JR, Cheng G, Picarella D, Briskin M, Buchanan N, von Andrian UH. Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin-and gut-associated lymphoid tissues. The Journal of experimental medicine. 2005;201(2):303-16. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
36. McDonald SL, Savy M, Fulford AJ, Kendall L, Flanagan KL, Prentice AM. A double blind randomized controlled trial in neonates to determine the effect of vitamin A supplementation on immune responses: The Gambia protocol. BMC pediatrics. 2014;14(1):92. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
37. Carman J, Hayes C. Abnormal regulation of IFN-gamma secretion in vitamin A deficiency. The Journal of Immunology. 1991;147(4):1247-52. [view at publisher] [Google Scholar]
38. Cantorna MT, Nashold FE, Hayes CE. In vitamin A deficiency multiple mechanisms establish a regulatory T helper cell imbalance with excess Th1 and insufficient Th2 function. The Journal of Immunology. 1994;152(4):1515-22. [view at publisher] [Google Scholar]
39. Jones LH, Cook PC, Ivens AC, Thomas G, D, Phythian-Adams AT, Allen JE, et al. Modulation of dendritic cell alternative activation and function by the vitamin A metabolite retinoic acid. International immunology. 2015;27(11):589-96. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
40. Surman SL, Jones BG, Rudraraju R, Sealy RE, Hurwitz JL. Intranasal administration of retinyl palmitate with a respiratory virus vaccine corrects impaired mucosal IgA response in the vitamin A-deficient host. Clin Vaccine Immunol. 2014;21(4):598-601. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
41. Rudraraju R, Jones BG, Surman SL, Sealy RE, Thomas PG, Hurwitz JL. Respiratory tract epithelial cells express retinaldehyde dehydrogenase ALDH1A and enhance IgA production by stimulated B cells in the presence of vitamin A. PLoS One. 2014;9(1). [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
42. Semba RD. The role of vitamin A and related retinoids in immune function. Nutrition reviews. 1998;56(1):S38-S48. [DOI] [PMID] [Google Scholar]
43. Xiao S, Jin H, Korn T, Liu SM, Oukka M, Lim B, et al. Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-β-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. The Journal of Immunology. 2008;181(4):2277-84. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
44. Behboudi E, Hamidi V, Gholizadeh F, Grala EM, Ghelmani Y, Nakhaie M, et al. Association between ABO blood groups and rhesus antigen and susceptibility to COVID-19 in the Yazd hospital. New Microbes and New infections. 2021;44:100934. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
45. Timoneda J, Rodríguez-Fernández L, Zaragozá R, Marín MP, Cabezuelo MT, Torres L, et al. Vitamin A Deficiency and the Lung. Nutrients. 2018;10(9). [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
46. Chew BP, Park JS. Carotenoid action on the immune response. The Journal of nutrition. 2004;134(1):257s-61s. [view at publisher] [DOI] [PMID] [Google Scholar]
47. Raverdeau M, Mills KH. Modulation of T cell and innate immune responses by retinoic Acid. Journal of immunology (Baltimore, Md : 1950). 2014;192(7):2953-8. [view at publisher] [DOI] [PMID] [Google Scholar]
48. Behboudi E, Shamsi A, Hamidi-Sofiani V, Oladnabi MJIJoP. The effects of fasting in Ramadan on the risk factors of COVID-19 in adolescents: a brief review. International Journal of Pediatrics. 2021;9(1):12835-42. [Google Scholar]
49. Surman SL, Rudraraju R, Sealy R, Jones B, Hurwitz JL. Vitamin A deficiency disrupts vaccine-induced antibody-forming cells and the balance of IgA/IgG isotypes in the upper and lower respiratory tract. Viral Immunol. 2012;25(4):341-4. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
50. Huang Z, Liu Y, Qi G, Brand D, Zheng SG. Role of Vitamin A in the Immune System. J Clin Med. 2018;7(9):258. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
51. Behboudi E, Hamidi-Sofiani V, Zeynali P. Review of Therapeutic Candidates for the New Corona Virus Disease (COVID-19). Razi Journal of Medical Sciences. 2020;27(8):65-77. [view at publisher] [Google Scholar]
52. Sarohan AR. COVID-19: Endogenous Retinoic Acid Theory and Retinoic Acid Depletion Syndrome. Med Hypotheses. 2020;144:110250-. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
53. Thirumdas R, Kothakota A, Pandiselvam R, Bahrami A, Barba FJ. Role of food nutrients and supplementation in fighting against viral infections and boosting immunity: A review. Trends in food science & technology. 2021;110:66-77. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
54. Brown ZA, Selke S, Zeh J, Kopelman J, Maslow A, Ashley RL, et al. The acquisition of herpes simplex virus during pregnancy. New England Journal of Medicine. 1997;337(8):509-16. [view at publisher] [DOI] [PMID] [Google Scholar]
55. Whitley RJ. Herpes simplex virus infections of women and their offspring: implications for a developed society. Proceedings of the National Academy of Sciences. 1994;91(7):2441-7. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
56. Katz E, Margalith E, Duksin D. Antiviral activity of tunicamycin on herpes simplex virus. Antimicrobial agents and chemotherapy. 1980;17(6):1014-22. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
57. Kousoulas KG, Bzik DJ, Deluca N, Person S. The effect of ammonium chloride and tunicamycin on the glycoprotein content and infectivity of herpes simplex virus type 1. Virology. 1983;125(2):468-74. [view at publisher] [DOI] [Google Scholar]
58. Isaacs CE, Xu W, Pullarkat RK, Kascsak R. Retinoic acid reduces the yield of herpes simplex virus in Vero cells and alters the N-glycosylation of viral envelope proteins. Antiviral research. 2000;47(1):29-40. [view at publisher] [DOI] [Google Scholar]
59. Guglielmi F, Panella C, Buda A, Budillon G, Caregaro L, Clerici C, et al. Nutritional state and energy balance in cirrhotic patients with or without hypermetabolism: multicentre prospective study by the 'Nutritional Problems in Gastroenterology'Section of the Italian Society of Gastroenterology (SIGE). Digestive and liver disease. 2005;37(9):681-8. [view at publisher] [DOI] [PMID] [Google Scholar]
60. Russell R, Iber F, Krasinski S, Miller P. Protein-energy malnutrition and liver dysfunction limit the usefulness of the relative dose response (RDR) test for predicting vitamin A deficiency. Human nutrition Clinical nutrition. 1983;37(5):361-71. [view at publisher] [Google Scholar]
61. Ukleja A, Scolapio JS, McConnell JP, Spivey JR, Dickson RC, Nguyen JH, et al. Nutritional assessment of serum and hepatic vitamin A levels in patients with cirrhosis. Journal of Parenteral and Enteral Nutrition. 2002;26(3):184-8. [view at publisher] [DOI] [PMID] [Google Scholar]
62. El-Eshmawy MM, Arafa MM, Elzehery RR, Elhelaly RM, Elrakhawy MM, El-Baiomy AA. Relationship between vitamin A deficiency and the thyroid axis in clinically stable patients with liver cirrhosis related to hepatitis C virus. Applied Physiology, Nutrition, and Metabolism. 2016;41(9):985-91. [DOI] [PMID] [Google Scholar]
63. Peres W, Chaves G, Gonçalves J, Ramalho A, Coelho H. Vitamin A deficiency in patients with hepatitis C virus-related chronic liver disease. British journal of nutrition. 2011;106(11):1724-31. [DOI] [PMID]
64. Tsiaousi ET, Hatzitolios AI, Trygonis SK, Savopoulos CG. Malnutrition in end stage liver disease: recommendations and nutritional support. Journal of gastroenterology and hepatology. 2008;23(4):527-33. [view at publisher] [DOI] [PMID] [Google Scholar]
65. De Maria N, Colantonl A, Fagiuoli S, Liu G-J, Rogers BK, Farinati F, et al. Association between reactive oxygen species and disease activity in chronic hepatitis C. Free Radical Biology and Medicine. 1996;21(3):291-5. [view at publisher] [DOI] [Google Scholar]
66. Bataller R, David A. Brenner Da. Liver fibrosis J Clin Invest. 2005;115:209-18. [DOI] [PMID] [PMCID] [Google Scholar]
67. Griswold MD. Spermatogenesis: the commitment to meiosis. Physiological reviews. 2016;96(1):1-17. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
68. Friedman SL, Wei S, Blaner WS. Retinol release by activated rat hepatic lipocytes: regulation by Kupffer cell-conditioned medium and PDGF. American Journal of Physiology-Gastrointestinal and Liver Physiology. 1993;264(5):G947-G52. [view at publisher] [DOI] [PMID] [Google Scholar]
69. O'Byrne SM, Wongsiriroj N, Libien J, Vogel S, Goldberg IJ, Baehr W, et al. Retinoid absorption and storage is impaired in mice lacking lecithin: retinol acyltransferase (LRAT). Journal of Biological Chemistry. 2005;280(42):35647-57. [DOI] [PMID] [PMCID] [Google Scholar]
70. Calamita Z, Dichi I, Papini-Berto SJ, Dichi JB, Angeleli A, Vannucchi H, et al. Plasma levels of transthyretin and retinol-binding protein in Child-A cirrhotic patients in relation to protein-calorie status and plasma amino acids, zinc, vitamin A and plasma thyroid hormones. Arquivos de gastroenterologia. 1997;34(3):139-47. [view at publisher] [Google Scholar]
71. Aubert J, Begriche K, Knockaert L, Robin M-A, Fromenty B. Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: mechanisms and pathophysiological role. Clinics and research in hepatology and gastroenterology. 2011;35(10):630-7. [view at publisher] [DOI] [PMID] [Google Scholar]
72. AhmedSM L. LevyK. Asystematicreview andmetaranalysisoftheglobalseasonalityofnorovirus. 2013;8(10):e75922. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
73. Hall AJ, Eisenbart VG, Etingüe AL, Gould LH, Lopman BA, Parashar UD. Epidemiology of foodborne norovirus outbreaks, United States, 2001-2008. Emerging infectious diseases. 2012;18(10):1566. [DOI] [PMID] [PMCID] [Google Scholar]
74. Nelson AM, Elftman MD, Pinto AK, Baldridge M, Hooper P, Kuczynski J, et al. Murine norovirus infection does not cause major disruptions in the murine intestinal microbiota. Microbiome. 2013;1(1):7. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
75. Long KZ, García C, Santos JI, Rosado JL, Hertzmark E, DuPont HL, et al. Vitamin A supplementation has divergent effects on norovirus infections and clinical symptoms among Mexican children. The Journal of infectious diseases. 2007;196(7):978-85. [view at publisher] [DOI] [PMID] [Google Scholar]
76. Thornton KA, Mora-Plazas M, Marín C, Villamor E. Vitamin A deficiency is associated with gastrointestinal and respiratory morbidity in school-age children. The Journal of nutrition. 2014;144(4):496-503. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
77. Takeuchi O, Akira S. Innate immunity to virus infection. Immunological reviews. 2009;227(1):75-86. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
78. Lee H, Ko G. New perspectives regarding the antiviral effect of vitamin A on norovirus using modulation of gut microbiota. Gut Microbes. 2017;8(6):616-20. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
79. Lee H, Ko G. Antiviral effect of vitamin A on norovirus infection via modulation of the gut microbiome. Scientific reports. 2016;6(1):1-9. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
80. Beaton GH. Effectiveness of vitamin A supplementation in the control of young child morbidity and mortality in developing countries. United Nations Subcommittee on Nutrition (SCN) News. 1993;9:17-23. [view at publisher] [Google Scholar]
81. Semba RD, Caiaffa WT, Graham NM, Cohn S, Vlahov D. Vitamin A deficiency and wasting as predictors of mortality in human immunodeficiency virus-infected injection drug users. Journal of Infectious Diseases. 1995;171(5):1196-202. [view at publisher] [DOI] [PMID] [Google Scholar]
82. Semba RD, Miotti PG, Chiphangwi JD, Liomba G, Yang L-P, Saah AJ, et al. Infant mortality and maternal vitamin A deficiency during human immunodeficiency virus infection. Clinical Infectious Diseases. 1995;21(4):966-72. [view at publisher] [DOI] [PMID] [Google Scholar]
83. Burns DN, FitzGerald G, Semba R, Hershow R, Zorrilla C, Pitt J, et al. Vitamin A deficiency and other nutritional indices during pregnancy in human immunodeficiency virus infection: prevalence, clinical correlates, and outcome. Clinical Infectious Diseases. 1999;29(2):328-34. [view at publisher] [DOI] [PMID] [Google Scholar]
84. Semba RD, Miotti P, Chiphangwi JD, Henderson R, Dallabetta G, Yang L-P, et al. Maternal vitamin A deficiency and child growth failure during human immunodeficiency virus infection. JAIDS Journal of Acquired Immune Deficiency Syndromes. 1997;14(3):219-22. [view at publisher] [DOI] [PMID] [Google Scholar]
85. Fawzi WW, Msamanga G, Hunter D, Urassa E, Renjifo B, Mwakagile D, et al. Randomized trial of vitamin supplements in relation to vertical transmission of HIV-1 in Tanzania. Journal of acquired immune deficiency syndromes (1999). 2000;23(3):246-54. [view at publisher] [DOI] [PMID] [Google Scholar]
86. Wiysonge CS, Ndze VN, Kongnyuy EJ, Shey MS. Vitamin A supplements for reducing mother‐to‐child HIV transmission. Cochrane Database of Systematic Reviews. 2017(9). [DOI] [PMID] [PMCID] [Google Scholar]
87. Filteau SM, Rollins NC, Coutsoudis A, Sullivan KR, Willumsen JF, Tomkins AM. The effect of antenatal vitamin A and β-carotene supplementation on gut integrity of infants of HIV-infected South African women. Journal of pediatric gastroenterology and nutrition. 2001;32(4):464-70. [view at publisher] [DOI] [PMID] [Google Scholar]
88. Hussey G, Hughes J, Potgieter S, Kessow G, Burgess J, Beatty D, et al., editors. Vitamin A status and supplementation and its effects on immunity in children with AIDS. Report of XVII IVACG Meeting; 1996. [Google Scholar]
89. Fawzi WW, Msamanga GI, Spiegelman D, Urassa EJ, McGrath N, Mwakagile D, et al. Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania. The Lancet. 1998;351(9114):1477-82. [view at publisher] [DOI] [Google Scholar]
90. Coutsoudis A, Pillay K, Spooner E, Kuhn L. Randomized trial testing the effect of vitamin A supplementation on pregnancy outcomes and early mother-to-child HIV-1 transmission in Durban, South Africa. Aids. 1999;13(12):1517-24. [view at publisher] [DOI] [PMID] [Google Scholar]
91. Kumwenda N, Miotti PG, Taha TE, Broadhead R, Biggar RJ, Jackson JB, et al. Antenatal vitamin A supplementation increases birth weight and decreases anemia among infants born to human immunodeficiency virus-infected women in Malawi. Clinical Infectious Diseases. 2002;35(5):618-24. [view at publisher] [DOI] [PMID] [Google Scholar]
92. Malaba LC, Iliff PJ, Nathoo KJ, Marinda E, Moulton LH, Zijenah LS, et al. Effect of postpartum maternal or neonatal vitamin A supplementation on infant mortality among infants born to HIV-negative mothers in Zimbabwe. The American journal of clinical nutrition. 2005;81(2):454-60. [view at publisher] [DOI] [PMID] [Google Scholar]
93. Semba RD, Graham NM, Caiaffa WT, Margolick JB, Clement L, Vlahov D. Increased mortality associated with vitamin A deficiency during human immunodeficiency virus type 1 infection. Archives of internal medicine. 1993;153(18):2149-54. [view at publisher] [DOI] [PMID] [Google Scholar]
94. Semba RD, Ndugwa C, Perry RT, Clark TD, Jackson JB, Melikian G, et al. Effect of periodic vitamin A supplementation on mortality and morbidity of human immunodeficiency virus-infected children in Uganda: a controlled clinical trial. Nutrition. 2005;21(1):25-31. [view at publisher] [DOI] [PMID] [Google Scholar]
95. Semba RD, Chiphangwi J, Miotti P, Dallabetta G, Hoover D, Canner J, et al. Maternal vitamin A deficiency and mother-to-child transmission of HIV-1. The Lancet. 1994;343(8913):1593-7. [view at publisher] [DOI] [Google Scholar]
96. Semba RD. Vitamin A and human immunodeficiency virus infection. Proceedings of the Nutrition Society. 1997;56(1B):459-69. [view at publisher] [DOI] [PMID] [Google Scholar]
97. John GC, Nduati RW, Mbori-Ngacha D, Overbaugh J, Welch M, Richardson BA, et al. Genital shedding of human immunodeficiency virus type 1 DNA during pregnancy: association with immunosuppression, abnormal cervical or vaginal discharge, and severe vitamin A deficiency. Journal of Infectious Diseases. 1997;175(1):57-62. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
98. Chen S, Yang Y, Yan X, Chen J, Yu H, Wang W. Influence of vitamin A status on the antiviral immunity of children with hand, foot and mouth disease. Clinical nutrition. 2012;31(4):543-8. [view at publisher] [DOI] [PMID] [Google Scholar]
99. Yang F, Ren L, Xiong Z, Li J, Xiao Y, Zhao R, et al. Enterovirus 71 outbreak in the People's Republic of China in 2008. Journal of clinical microbiology. 2009;47(7):2351-2. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
100. Wei D, Yang Y, Wang W. The expression of retinoic acid receptors in lymph nodes of young children and the effect of all-trans-retinoic acid on the B cells from lymph nodes. Journal of clinical immunology. 2007;27(1):88. [view at publisher] [DOI] [PMID] [Google Scholar]
101. Zhou X, Wang W, Yang Y. The expression of retinoic acid receptors in thymus of young children and the effect of all-transretinoic acid on the development of T cells in thymus. Journal of clinical immunology. 2008;28(1):85-91. [view at publisher] [DOI] [PMID] [Google Scholar]
102. Chen S, Yang Y, Xu J, Su L, Wang W. Effect of all-trans-retinoic acid on enterovirus 71 infection in vitro. British Journal of Nutrition. 2014;111(9):1586-93. [view at publisher] [DOI] [PMID] [Google Scholar]
103. Wang S-M, Chen I-C, Su L-Y, Huang K-J, Lei H-Y, Liu C-C. Enterovirus 71 infection of monocytes with antibody-dependent enhancement. Clin Vaccine Immunol. 2010;17(10):1517-23. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
104. Soye KJ, Trottier C, Richardson CD, Ward BJ, Miller Jr WH. RIG-I is required for the inhibition of measles virus by retinoids. PloS one. 2011;6(7). [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
105. Luo XM, Ross AC. Physiological and receptor-selective retinoids modulate interferon γ signaling by increasing the expression, nuclear localization, and functional activity of interferon regulatory factor-1. Journal of Biological Chemistry. 2005;280(43):36228-36. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
106. Dimberg A, Nilsson K, Öberg F. Phosphorylation-deficient Stat1 inhibits retinoic acid-induced differentiation and cell cycle arrest in U-937 monoblasts. Blood, The Journal of the American Society of Hematology. 2000;96(8):2870-8. [view at publisher] [DOI] [Google Scholar]
107. Lu J, Yi L, Zhao J, Yu J, Chen Y, Lin MC, et al. Enterovirus 71 disrupts interferon signaling by reducing the level of interferon receptor 1. Journal of virology. 2012;86(7):3767-76. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
108. Huang H-I, Weng K-F, Shih S-R. Viral and host factors that contribute to pathogenicity of enterovirus 71. Future microbiology. 2012;7(4):467-79. [view at publisher] [DOI] [PMID] [Google Scholar]
109. Gianni M, Terao M, Fortino I, LiCalzi M, Viggiano V, Barbui T, et al. Stat1 is induced and activated by all-trans retinoic acid in acute promyelocytic leukemia cells. Blood, The Journal of the American Society of Hematology. 1997;89(3):1001-12. [view at publisher] [DOI] [Google Scholar]
110. Pfister H. The role of human papillomavirus in anogenital cancer. Obstetrics and gynecology clinics of North America. 1996;23(3):579-95. [view at publisher] [Google Scholar]
111. Dürst M, Dzarlieva-Petrusevska R, Boukamp P, Fusenig N, Gissmann L. Molecular and cytogenetic analysis of immortalized human primary keratinocytes obtained after transfection with human papillomavirus type 16 DNA. Oncogene. 1987;1(3):251-6. [view at publisher] [Google Scholar]
112. Kaur P, McDOUGALL JK. Characterization of primary human keratinocytes transformed by human papillomavirus type 18. Journal of virology. 1988;62(6):1917-24. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
113. Pirisi L, Yasumoto S, Feller M, Doniger J, DiPAOLO JA. Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA. Journal of virology. 1987;61(4):1061-6. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
114. Pirisi L, Creek KE, Doniger J, Dipaolo JA. Continuous cell lines with altered growth and differentiation properties originate after transfection of human keratinocytes with human papillomavirus type 16 DNA. Carcinogenesis. 1988;9(9):1573-9. [view at publisher] [DOI] [PMID] [Google Scholar]
115. Woodworth C, Bowden PE, Doniger J, Pirisi L, Barnes W, Lancaster W, et al. Characterization of normal human exocervical epithelial cells immortalized in vitro by papillomavirus types 16 and 18 DNA. Cancer research. 1988;48(16):4620-8. [view at publisher] [Google Scholar]
116. Woodworth C, Doniger J, DiPaolo J. Immortalization of human foreskin keratinocytes by various human papillomavirus DNAs corresponds to their association with cervical carcinoma. Journal of Virology. 1989;63(1):159-64. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
117. Zyzak LL, MacDonald LM, Batova A, Forand R, Creek KE, Pirisi L. Increased levels and constitutive tyrosine phosphorylation of the epidermal growth factor receptor contribute to autonomous growth of human papillomavirus type 16 immortalized human keratinocytes. Cell Growth and Differentiation-Publication American Association for Cancer Research. 1994;5(5):537-48. [view at publisher] [Google Scholar]
118. DiPaolo J, Woodworth C, Popescu N, Notario V, Doniger J. Induction of human cervical squamous cell carcinoma by sequential transfection with human papillomavirus 16 DNA and viral Harvey ras. Oncogene. 1989;4(4):395-9. [view at publisher] [Google Scholar]
119. Dipaolo JA, Woodworth CD, Popescu NC, Koval DL, Lopez JV, Doniger J. HSV-2-induced tumorigenicity in HPV16-immortalized human genital keratinocytes. Virology. 1990;177(2):777-9. [view at publisher] [DOI] [Google Scholar]
120. Pirisi L, Batova A, Jenkins GR, Hodam JR, Creek KE. Increased sensitivity of human keratinocytes immortalized by human papillomavirus type 16 DNA to growth control by retinoids. Cancer research. 1992;52(1):187-93. [view at publisher] [Google Scholar]
121. Khan MA, Jenkins GR, Tolleson WH, Creek KE, Pirisi L. Retinoic acid inhibition of human papillomavirus type 16-mediated transformation of human keratinocytes. Cancer research. 1993;53(4):905-9. [view at publisher] [Google Scholar]
122. Creek KE, Jenkins GR, Khan MA, Batova A, Hodam JR, Tolleson WH, et al. Retinoic acid suppresses human papillomavirus type 16 (HPV16)-mediated transformation of human keratinocytes and inhibits the expression of the HPV16 oncogenes. Diet and Cancer: Springer; 1994. p. 19-35. [view at publisher] [DOI] [PMID] [Google Scholar]
123. Shipley GD, Pittelkow MR, Wille JJ, Scott RE, Moses HL. Reversible inhibition of normal human prokeratinocyte proliferation by type β transforming growth factor-growth inhibitor in serum-free medium. Cancer research. 1986;46(4 Part 2):2068-71. [view at publisher] [Google Scholar]
124. Coffey RJ, Sipes NJ, Bascom CC, Graves-Deal R, Pennington CY, Weissman BE, et al. Growth modulation of mouse keratinocytes by transforming growth factors. Cancer research. 1988;48(6):1596-602. [view at publisher] [Google Scholar]
125. Batova A, Danielpour D, Pirisi L, Creek K. Retinoic acid induces secretion of latent transforming growth factor beta 1 and beta 2 in normal and human papillomavirus type 16-immortalized human keratinocytes. Cell growth & differentiation: the molecular biology journal of the American Association for Cancer Research. 1992;3(11):763-72. [view at publisher] [Google Scholar]
126. Woodworth C, Notario V, DiPaolo J. Transforming growth factors beta 1 and 2 transcriptionally regulate human papillomavirus (HPV) type 16 early gene expression in HPV-immortalized human genital epithelial cells. Journal of virology. 1990;64(10):4767-75. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
127. Borger DR, Geslani G, Zyzak LL, Batova A, Engin TS, Pirisi L, et al. Retinoic acid resistance at late stages of human papillomavirus type 16-mediated transformation of human keratinocytes arises despite intact retinoid signaling and is due to a loss of sensitivity to transforming growth factor-β. Virology. 2000;270(2):397-407. [view at publisher] [DOI] [PMID] [Google Scholar]
128. Harris P, Ralph P. Human leukemic models of myelomonocytic development: a review of the HL‐60 and U937 cell lines. Journal of leukocyte biology. 1985;37(4):407-22. [view at publisher] [DOI] [PMID] [Google Scholar]
129. Fujii N, Yokosawa N, Ishida S, Shirakawa S, Kubota T, Indoh T, et al. Investigation of IFN type-I receptor and IFN regulatory factor expression relating to induction of 2', 5'-oligoadenylate synthetase in cells persistently infected with the mumps virus. Microbiology and immunology. 1996;40(10):777-81. [view at publisher] [DOI] [PMID] [Google Scholar]
130. Indoh T, Shirakawa S, Kubota T, Yashiki T, Isogai E, Fujii N. Augmentation of interferon production after cell-differentiation of U937 cells by TPA. Microbiology and immunology. 1996;40(9):675-9. [view at publisher] [DOI] [PMID] [Google Scholar]
131. Hariya Y, Yokosawa N, Yonekura N, Kohama Gi, Fujii N. Mumps Virus Can Suppress the Effective Augmentation of HPC‐Induced Apoptosis by IFN‐γ through Disruption of IFN Signaling in U937 Cells. Microbiology and immunology. 2000;44(6):537-41. [view at publisher] [DOI] [PMID] [Google Scholar]
132. Soye KJ, Trottier C, Di Lenardo TZ, Restori KH, Reichman L, Miller WH, et al. In vitro inhibition of mumps virus by retinoids. Virology journal. 2013;10(1):337. [view at publisher] [DOI] [PMID] [PMCID] [Google Scholar]
133. Percario ZA, Giandomenico V, Fiorucci G, Chiantore MV, Vannucchi S, Hiscott J, et al. Retinoic acid is able to induce interferon regulatory factor 1 in squamous carcinoma cells via a STAT-1 independent signalling pathway. Cell Growth and Differentiation-Publication American Association for Cancer Research. 1999;10(4):263-70. [Google Scholar]
134. Arany I, Whitehead WE, Grattendick KJ, Ember IA, Tyring SK. Suppression of growth by all-trans retinoic acid requires prolonged induction of interferon regulatory factor 1 in cervical squamous carcinoma (SiHa) cells. Clin Diagn Lab Immunol. 2002;9(5):1102-6. [DOI] [PMID] [PMCID] [Google Scholar]

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.